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Related Experiment Videos

Amyloidosis and pleural disease.

M S Kavuru1, J P Adamo, M Ahmad

  • 1Department of Pulmonary Disease, Cleveland Clinic Foundation.

Chest
|July 1, 1990
PubMed
Summary

Systemic amyloidosis rarely affects the pleura. A Cope needle biopsy can diagnose pleural amyloidosis, even with transudative effusions, simplifying diagnosis in patients with suspected multiorgan involvement.

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Area of Science:

  • Pulmonology
  • Pathology
  • Internal Medicine

Background:

  • Systemic amyloidosis is a rare condition with infrequent pleural involvement.
  • Diagnosing pleural amyloidosis via percutaneous needle biopsy is seldom reported.

Observation:

  • This study describes five patients diagnosed with pleural amyloidosis using Cope needle biopsy for unexplained pleural effusions.
  • Three patients with suspected multiorgan disease were diagnosed via pleural biopsy despite transudative effusions, avoiding other organ biopsies.

Findings:

  • Cope needle biopsy successfully diagnosed pleural amyloidosis in all five patients.
  • The procedure proved effective even when pleural effusions were transudative, suggesting systemic amyloidosis.

Implications:

  • A closed pleural biopsy with special stains for amyloid is recommended for patients with pleural effusions and suspected systemic amyloidosis, even if effusions are transudative.
  • This diagnostic approach may obviate the need for biopsies of other organs, streamlining patient evaluation.

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