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Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

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Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity
07:13

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Published on: January 6, 2015

CT air trapping is independently associated with lung function reduction over time.

Onno M Mets1, Pim A de Jong, Bram van Ginneken

  • 1Radiology, University Medical Center Utrecht, Utrecht, The Netherlands. metsonno@gmail.com

Plos One
|April 25, 2013
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Quantitative CT air trapping in smokers is linked to reduced lung function, specifically forced expiratory volume in one second (FEV1) and FEV1/FVC ratio. This air trapping also accelerates the decline in FEV1/FVC over time.

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Area of Science:

  • Pulmonary Medicine
  • Radiology
  • Quantitative Imaging

Background:

  • Lung function decline is a hallmark of chronic lung diseases.
  • Air trapping, a physiological consequence of airflow obstruction, is a key feature.
  • Accurate quantification of air trapping is crucial for understanding disease progression.

Purpose of the Study:

  • To investigate the association between quantitative computed tomography (CT) air trapping and lung function decline.
  • To determine if CT-assessed air trapping is an independent predictor of lung function changes.

Main Methods:

  • Volumetric low-dose CT scans (inspiration and expiration) were performed on 985 current and former heavy smokers.
  • Air trapping was quantified using the expiratory to inspiratory ratio of mean lung density (E/I-ratioMLD).
  • Linear mixed modeling analyzed the association between CT air trapping and spirometry measures (FEV1, FEV1/FVC) over 3 years.

Main Results:

  • CT air trapping was significantly associated with reduced forced expiratory volume in one second (FEV1) and FEV1/FVC ratio, independent of CT emphysema.
  • FEV1 declined by 33 mL and FEV1/FVC by 0.58% per percent increase in CT air trapping.
  • CT air trapping demonstrated an accelerated decline in FEV1/FVC, with an additional 0.24% reduction per percent increase.

Conclusions:

  • Quantitative air trapping on low-dose CT is independently associated with reduced lung function in smokers.
  • CT-assessed air trapping predicts both current lung function impairment and its future decline.
  • This imaging biomarker may aid in risk stratification and monitoring of lung disease progression.