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Updated: May 12, 2026
08:32
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
[Research progress in nitric oxide biosynthesis, degradation and function in fungi]
Yiduo Chen1, Zhen Zhang, Hua Jiang
1College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, China. chenyiduo5566@163.com
Wei Sheng Wu Xue Bao = Acta Microbiologica Sinica
|April 26, 2013
Summary
Nitric oxide (NO) is a vital signaling molecule in fungi, regulating development and reproduction. While essential in appropriate amounts, excessive NO can harm fungal cells and trigger apoptosis.
Area of Science:
- Mycology
- Biochemistry
- Cell Biology
Context:
- Nitric oxide (NO) is a critical signaling molecule in animals and plants.
- Fungi are increasingly recognized for their capacity to synthesize and utilize NO.
- The precise roles and mechanisms of NO in fungal systems remain underexplored.
Purpose:
- To review the current understanding of nitric oxide's role in fungal physiology.
- To highlight the dual functions of NO in fungal cells, encompassing both beneficial and detrimental effects.
- To identify knowledge gaps regarding NO synthesis, degradation, and signal transduction in fungi.
Summary:
- Nitric oxide (NO) acts as an intra- and inter-cellular messenger in fungi, influencing key processes like development, morphogenesis, sporulation, germination, reproduction, and apoptosis.
- Appropriate levels of NO are crucial for normal fungal cell function, whereas excessive NO can lead to cellular damage and programmed cell death (apoptosis).
- NO modulates cyclic guanosine monophosphate (cGMP) synthesis, a secondary messenger involved in fungal signal transduction pathways.
Impact:
- This review underscores the significance of nitric oxide in fungal life cycles.
- It emphasizes the need for further research into NO's biochemical pathways and signaling mechanisms in fungi.
- Understanding NO's role can lead to novel strategies for controlling fungal growth and development.
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