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Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

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Secondary Lymphoid Organs

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The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Pulmonary Tuberculosis IV

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Endocarditis II: Clinical Features of Infective Endocarditis

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Updated: May 12, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Nodular secondary syphilis simulating lepromatous leprosy.

Kathryn Margaret Dupnik¹, Milena Maria Costa Martins, Ana Teresa Da Silva Souza

¹Division of Infectious Diseases, Weill Cornell Medical College, New York, NY, USA.

|April 26, 2013

Summary

Skin manifestations of leprosy and syphilis can be similar, causing diagnostic challenges. This case highlights nodular syphilis mimicking lepromatous leprosy in an endemic region.

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Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

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Last Updated: May 12, 2026

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Area of Science:

Dermatology
Infectious Diseases
Syphilology

Background:

Leprosy and syphilis present diverse skin manifestations that can mimic other dermatologic and systemic conditions.
Accurate diagnosis is crucial, especially in leprosy-endemic areas where overlapping clinical presentations can occur.

Observation:

A patient from a leprosy-endemic region presented with diffuse nodular skin lesions.
The initial clinical suspicion was lepromatous leprosy due to the nodular presentation.

Findings:

The patient was diagnosed with nodular syphilis, an uncommon form of secondary syphilis.
This case underscores the importance of considering syphilis in the differential diagnosis of nodular skin lesions, even in endemic settings.

Implications:

This case highlights the diagnostic challenges posed by similar-appearing skin lesions in infectious diseases.
Clinicians should maintain a high index of suspicion for syphilis when encountering nodular dermatoses, particularly in regions co-endemic for leprosy.
Broadening the differential diagnosis can prevent misdiagnosis and ensure timely, appropriate treatment.