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Related Concept Videos

Sensory Functions of the Skin01:16

Sensory Functions of the Skin

The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Introduction to the Integumentary System01:25

Introduction to the Integumentary System

The integumentary system is the organ system that comprises the skin and its associated structures. It is the largest system in the human body and plays a crucial role in protecting and maintaining homeostasis. The integumentary system serves several functions including protection, regulation, sensation, and secretion.
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).

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Related Experiment Video

Updated: May 12, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
07:40

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

[How I explore ... the skin functional involvement in scleroderma].

T Hermanns-Lê1, C Piérard-Franchimont, G E Piérard

  • 1Service de Dermatopathologie, CHU de Liège, Belgique. trinh.hermanns@chu.ulg.ac.be

Revue Medicale De Liege
|April 26, 2013
PubMed
Summary
This summary is machine-generated.

Scleroderma involves skin hardening, affecting either the skin alone or internal organs. Measuring skin mechanical properties offers valuable insights into disease severity and treatment effectiveness.

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Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
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Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

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Last Updated: May 12, 2026

Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
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Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay

Published on: April 28, 2022

Demonstrating Hairy and Glabrous Skin Innervation in a 3D Pattern Using Multiple Fluorescent Staining and Tissue Clearing Approaches
05:23

Demonstrating Hairy and Glabrous Skin Innervation in a 3D Pattern Using Multiple Fluorescent Staining and Tissue Clearing Approaches

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Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology
13:58

Flat Mount Imaging of Mouse Skin and Its Application to the Analysis of Hair Follicle Patterning and Sensory Axon Morphology

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Area of Science:

  • Dermatology
  • Rheumatology
  • Biomedical Engineering

Context:

  • Scleroderma encompasses various conditions characterized by skin hardening.
  • Manifestations range from localized morphea to systemic sclerosis with internal organ involvement.
  • Objective, non-invasive assessments are crucial for disease management.

Purpose:

  • To explore the utility of in vivo skin mechanical property measurements.
  • To evaluate these measurements for assessing scleroderma severity and progression.
  • To determine their role in monitoring therapeutic efficacy.

Summary:

  • Scleroderma is a group of diseases causing skin hardening.
  • Systemic sclerosis can affect internal organs alongside the skin.
  • In vivo measurement of skin mechanical properties provides informative data.

Impact:

  • In vivo skin mechanical testing can enhance the objective assessment of scleroderma.
  • This approach aids in monitoring disease evolution and treatment response.
  • It offers a non-invasive method to evaluate disease severity.