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Detection of claudin-4 in salivary gland neoplasms (a study utilizing RT-PCR and immunohistochemistry)
Safa F Abd El-Ghani1, Rehab F Kasem, Noha A Ghallab
1Department of Oral Pathology, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
Background:
Claudins are transmembrane proteins of tight junctions emerging as targets for diagnosis, prediction of prognosis, disease recurrence, and metastasis. Our goal was to evaluate expression of claudin-4 in the most common benign and malignant salivary gland neoplasms.
Methods:
Claudin-4 gene levels and protein expression were determined by real-time polymerase chain reaction (PCR), and immunohistochemistry in a total of 30 specimens containing normal salivary tissue, pleomorphic adenoma, Warthin's tumor, mucoepidermoid carcinoma, and adenoid cystic carcinoma.
Results:
We identified down-regulation of claudin-4 gene levels and protein expression from normal control to benign salivary gland neoplasms and reached their lowest values in the malignant salivary gland neoplasms.
Conclusions:
Low claudin-4 expression could be considered as a sign of increasing cellular disorientation and invasion of salivary gland tumors.
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