Related Experiment Video

Updated: May 12, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Sirtuins family--recent development as a drug target for aging, metabolism, and age related diseases

Chiranjib Chakraborty1, C George Priya Doss

  • 1Department of Bio-informatics, School of Computer and Information Sciences, Galgotias University, Greater Noida, India. drchiranjib@yahoo.com

Current Drug Targets
|April 26, 2013
PubMed

Insights

Silent information regulator 2 (sirtuins) are proteins influencing aging and age-related diseases. This review covers sirtuin discovery, functions, and therapeutic potential for aging conditions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Gerontology

Background:

  • Silent information regulator 2 (Sir2) proteins, known as sirtuins, are crucial regulators of cellular processes.
  • Sirtuins play significant roles in aging, metabolism, and the development of age-related diseases.

Purpose of the Study:

  • To summarize the discovery and enzymatic activities of the Sir2 protein family.
  • To review the involvement of sirtuins in aging, lifespan, and age-related symptom onset.
  • To highlight the association of mammalian sirtuins with aging, metabolism, and age-related diseases.

Main Methods:

  • Literature review and synthesis of existing research on sirtuins.
  • Analysis of sirtuin functions in aging and disease models.
  • Examination of recent findings on sirtuin targets and drug discovery.

Main Results:

  • Sirtuins are involved in diverse physiological responses, impacting aging and disease.
  • Mammalian sirtuins are linked to metabolic regulation and various age-related pathologies.
  • Recent research focuses on small molecules and drug discovery targeting sirtuins for therapeutic intervention.

Conclusions:

  • Understanding mammalian sirtuins is key to addressing age-related diseases.
  • Targeting sirtuins offers a promising therapeutic strategy for aging conditions.
  • Further research into sirtuin pathways can lead to novel treatments for diseases of aging.

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