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Updated: May 12, 2026

Direct Cannula Implantation in the Cisterna Magna of Pigs
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The indusium griseum: anatomic study with potential application to callosotomy.

R Shane Tubbs1, Matthew Prekupec, Marios Loukas

  • 1*Pediatric Neurosurgery, Children's Hospital, Birmingham, Alabama; ‡Department of Anatomical Sciences, St. George's University School of Medicine, St. George's, Grenada; §Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, and IU Health Pathology Laboratory, Indianapolis, Indiana; ¶Goodman Campbell Brain and Spine, Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Neurosurgery
|April 26, 2013
PubMed
Summary

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The indusium griseum (IG) is a glial membrane, not connected to the hippocampus. Its transection during callosotomy is unlikely to cause memory loss.

Area of Science:

  • Neuroanatomy
  • Histology
  • Neuroscience

Background:

  • The indusium griseum (IG) anatomy is poorly understood.
  • Its potential connection to the hippocampus and role in memory deficits post-callosotomy are debated.

Purpose of the Study:

  • To investigate the human indusium griseum (IG) anatomy via gross and histological analysis.

Main Methods:

  • Microdissection and immunohistochemical analysis of the IG from 10 adult cadaveric brains.

Main Results:

  • Grossly, the IG is a 2 cm wide membrane over the corpus callosum (CC), adhering to surrounding structures.
  • Histologically, it's a thin, hypocellular glial layer, hypomyelinated compared to the CC, with perpendicular fiber orientation and variable thickness.

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Conclusions:

  • The IG is a glial membrane without neuronal content or hippocampal connections.
  • Transection of the IG during callosotomy is unlikely to be the cause of postoperative memory deficits.
  • Further research is needed to determine the human IG's function.