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Updated: May 12, 2026

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
Published on: December 31, 2013
What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel?
Alex Perálvarez-Marín1, Pau Doñate-Macian, Rachelle Gaudet
1Centre d'Estudis en Biofísica, Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Cerdanyola del Vallés, Spain.
Abstract:
Transient receptor potential (TRP) ion channels are emerging as a new set of membrane proteins involved in a vast array of cellular processes and regulated by a large number of physical and chemical stimuli, which involves them with sensory cell physiology. The vanilloid TRP subfamily (TRPV) named after the vanilloid receptor 1 (TRPV1) consists of six members, and at least four of them (TRPV1-TRPV4) have been related to thermal sensation. One of the least characterized members of the TRP subfamily is TRPV2. Although initially characterized as a noxious heat sensor, TRPV2 now seems to have little to do with temperature sensing but a much more complex physiological profile. Here we review the available information and research progress on the structure, physiology and pharmacology of TRPV2 in an attempt to shed some light on the physiological and pharmacological deorphanization of TRPV2.
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