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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Factors affecting Blood pressure

Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
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Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...

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Related Experiment Video

Updated: May 12, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Soluble ST2 predicts elevated SBP in the community.

Jennifer E Ho1, Martin G Larson, Anahita Ghorbani

  • 1Framingham Heart Study of the National Heart, Lung and Blood Institute and Boston University School of Medicine, Framingham, Massachusetts, USA.

Journal of Hypertension
|April 26, 2013
PubMed
Summary
This summary is machine-generated.

Soluble ST2 (sST2) predicts hypertension development and blood pressure increases, particularly systolic and pulse pressure. This biomarker may indicate aging-related vascular changes and arterial stiffness.

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Last Updated: May 12, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Research
  • Hypertension Studies

Background:

  • Soluble ST2 (sST2) is an emerging prognostic biomarker in cardiovascular disease.
  • The ST2/interleukin-33 (IL-33) pathway is implicated in early atherosclerosis and vascular biology.
  • Endothelial cell expression of ST2/IL-33 suggests a role in blood pressure regulation.

Purpose of the Study:

  • Investigate the association between sST2 concentrations and blood pressure (BP) progression.
  • Examine the relationship between sST2 and the development of hypertension.
  • Assess sST2 as a predictor of longitudinal BP changes.

Main Methods:

  • Measured circulating sST2 concentrations in 1834 participants from the Framingham Offspring study.
  • Included individuals free of hypertension at baseline (mean age 56 years, 57% women).
  • Utilized multivariable regression models to analyze associations between sST2 and BP outcomes over 3 years.

Main Results:

  • Higher sST2 concentrations were linked to a greater risk of developing hypertension (OR 1.22 per SD increase).
  • Individuals in the highest sST2 quartile showed significantly greater increases in systolic BP and pulse pressure compared to the lowest quartile.
  • No significant association was found between sST2 concentrations and changes in diastolic BP.

Conclusions:

  • sST2 concentrations may predict physiological changes in BP associated with aging and arterial stiffness.
  • The ST2/IL-33 pathway warrants further investigation for its role in BP regulation.
  • sST2 emerges as a potential biomarker for hypertension risk and vascular aging.