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Intracranial tuberculoma in non-immunosuppressive state
Yoshihisa Matsumoto1, Hiroshi Aikawa, Sumito Narita
1Department of Neurosurgery, Fukuoka University Chikushi Hospital, Fukuoka 818-8502, Japan.
Neurologia Medico-Chirurgica
|April 26, 2013
Summary
Intracranial tuberculoma can occur without immunosuppression. The QuantiFERON Test (QFT) aids diagnosis in these atypical tuberculosis cases.
Area of Science:
- Neurology
- Infectious Diseases
- Radiology
Background:
- Tuberculosis (TB) incidence is rising, often linked to HIV.
- Intracranial tuberculoma is a severe TB complication.
- It can manifest even without immunosuppression or prior TB history.
Observation:
- Two cases of intracranial tuberculoma presented in patients without immunosuppression or TB history.
- Case 1: Lesions in the right lateral ventricle with granulomatous changes.
- Case 2: Lesions in the cranium and lung fields.
Findings:
- Both patients had positive QuantiFERON Tests (QFT).
- Antituberculous drug administration led to symptom improvement.
- QFT proved effective for diagnosing tuberculomas in atypical presentations.
Implications:
- Intracranial tuberculoma should be considered in differential diagnoses for intracranial lesions.
- Diagnosis is challenging in non-immunosuppressed patients or those with no TB history.
- QFT is a valuable tool for identifying tuberculomas in unusual cases.
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