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The protective effects of β-cryptoxanthin on inflammatory bone resorption in a mouse experimental model of
Chiho Matsumoto1, Noriyuki Ashida, Satoshi Yokoyama
1Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Bioscience, Biotechnology, and Biochemistry
|April 26, 2013
Abstract:
We examined the effects of β-cryptoxanthin, a typical carotenoid, on inflammatory periodontitis. β-Cryptoxanthin suppressed lipopolysaccharide (LPS)-induced osteoclast formation in co-cultures of bone marrow cells and osteoblasts. In a mouse model of periodontitis, it suppressed bone resorption in the mandibular alveolar bone in vitro and restored alveolar bone loss induced by LPS in vivo. β-Cryptoxanthin might protect against periodontal disease.
