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Updated: May 12, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
Maternal obesity and pre-pregnancy folic acid supplementation
Nadine Farah1, Cormac Kennedy, Ciara Turner
1UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, Ireland. drnfarah@gmail.com
Objective:
The purpose of this nested cohort study was to compare the rate of pre-pregnancy supplementation in obese women with that of women with a normal BMI.
Methods:
Pregnant women were enrolled at their convenience in a large university hospital. Weight and height were measured in the first trimester and BMI categorised.
Results:
Of the 288 women, 35.1% were in the normal, 29.5% in the overweight and 35.4% in the obese BMI categories. Only 45.1% (n = 46) of the obese women took pre-pregnancy folic acid compared with 60.4% (n = 61) of women with a normal BMI (p < 0.03). The lower incidence of folic acid supplementation in obese women was associated with an unplanned pregnancy in 36.3% of women compared with 22.8% in the normal BMI category (p < 0.04).
Conclusions:
Obese women should take folate supplements whether they are planning to conceive or not.
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