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Updated: May 12, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Ridge augmentation using customized allogenic bone blocks: proof of concept and histological findings
Markus Schlee1, Daniel Rothamel
1Department of Oral Surgery, Goethe University, Frankfurt, Germany. markus.schlee@32schoenezaehne.de
Aim:
To evaluate handling and healing patterns of customized allogenic bone blocks for vertical and horizontal alveolar defect augmentation.
Materials And Methods:
In 2 patients, 3 combined horizontal and vertical post-foraminal mandibular defects were grafted using computer-aided design (CAD) trimmed individual block grafts, 3D-designed on preoperative computed tomography scans. After a healing period of 6 months, graft resorption was measured and bone trephines were taken in progress of implant bed preparation. Four months later, implants were restored with single crowns. Moreover, clinical and radiological implant parameters were assessed 6 and 12 months after restorative rehabilitation.
Results:
Uneventful healing was observed in 2 of the 3 cases. A partial exposure of 1 block after 8 weeks could be successfully treated by block reduction and application of a soft tissue graft. Histological evaluation revealed predictable bone formation within all augmented areas, and both patient satisfaction and long-term stability parameters were considered excellent.
Conclusions:
It was concluded that the application of individual CAD allografts supports bone formation at deficient sites with reduced patient morbidity, decreased surgery time, and high patient acceptance.
