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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

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Published on: September 9, 2012

Evolution of Factor V Leiden.

Thijs E van Mens1, Marcel Levi, Saskia Middeldorp

  • 1Department of Vascular Medicine, F4-276, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. t.e.vanmens@amc.uva.nl

Thrombosis and Haemostasis
|April 26, 2013
PubMed
Summary
This summary is machine-generated.

Factor V Leiden mutation carriers may have evolutionary advantages, including reduced blood loss and increased fertility. However, not all reported benefits are well-supported by research.

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Published on: August 14, 2017

Area of Science:

  • Genetics
  • Evolutionary Biology
  • Hematology

Background:

  • Factor V Leiden is a common procoagulant mutation in Caucasians, linked to thrombosis and pregnancy issues.
  • Its high prevalence suggests potential evolutionary advantages.
  • Reported benefits include altered hemostasis, inflammation, and fertility.

Purpose of the Study:

  • To explore the potential evolutionary benefits of the Factor V Leiden mutation.
  • To review reported advantageous phenotypes associated with Factor V Leiden carriage.
  • To discuss possible mechanistic explanations for these associations.

Main Methods:

  • Review of existing literature on Factor V Leiden and associated phenotypes.
  • Analysis of reported associations with hemostasis, inflammation, fertility, and disease susceptibility.
  • Discussion of potential biological mechanisms, such as activated protein C (APC) resistance.

Main Results:

  • Factor V Leiden carriers may experience less blood loss and reduced risk of intracranial hemorrhage.
  • Potential benefits include milder hemophilia, increased sepsis survival, and improved outcomes in ARDS and diabetic nephropathy.
  • Increased fecundity in both sexes is linked to higher sperm counts and successful embryo implantation.

Conclusions:

  • While Factor V Leiden has thrombotic risks, it may confer evolutionary advantages.
  • Mechanisms like APC resistance and elevated APC levels likely mediate some benefits.
  • Further high-quality research is needed to confirm many reported associations and their evolutionary significance.