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Related Concept Videos

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Organization of the Brain01:30

Organization of the Brain

The brain is an integral component of the nervous system and serves as the center for processing sensory inputs, making decisions, and directing bodily actions. This complex organ is organized into three primary sections: the hindbrain, midbrain, and forebrain, each responsible for a range of vital functions.
Hindbrain
The hindbrain, located at the base of the brain, plays a vital role in regulating automatic processes that sustain life. It includes the medulla oblongata, which is essential for...

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Related Experiment Video

Updated: May 12, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
07:28

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

Genomics and proteomics in solving brain complexity.

Beena M Kadakkuzha1, Sathyanarayanan V Puthanveettil

  • 1Department of Neuroscience, The Scripps Research Institute, Scripps Florida 130 Scripps Way, Jupiter, FL 33458, USA.

Molecular Biosystems
|April 26, 2013
PubMed
Summary

Neuroscience research uses advanced sequencing and bioinformatics to explore how brain cells use gene expression for cognition and how this is altered in neurological disorders.

Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • The human brain's complexity arises from billions of neurons and trillions of synapses.
  • Neural circuits involve neurons, interneurons, glia, and astrocytes, each expressing thousands of genes and noncoding RNAs.

Purpose of the Study:

  • To understand how neural circuits utilize gene expression potential during development and for cognitive functions.
  • To investigate alterations in gene expression associated with neurological and psychiatric disorders.

Main Methods:

  • Review of recent advances in next-generation sequencing.
  • Integration of proteomics and bioinformatics approaches.
  • Analysis of gene expression patterns in neural circuitry.

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DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data
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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

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Last Updated: May 12, 2026

JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics

Published on: October 19, 2021

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data
09:47

DeepOmicsAE: Representing Signaling Modules in Alzheimer's Disease with Deep Learning Analysis of Proteomics, Metabolomics, and Clinical Data

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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
11:49

Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue

Published on: August 28, 2021

Main Results:

  • Next-generation sequencing, proteomics, and bioinformatics have significantly advanced our understanding.
  • Insights into the role of gene expression in neural circuitry function.
  • Understanding of gene expression's role in memory storage and cognitive disorders.

Conclusions:

  • Technological advancements are revolutionizing neuroscience research.
  • Understanding gene expression is crucial for deciphering brain function and disease.
  • This knowledge is key to addressing neurological and psychiatric conditions.