Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preclinical Development: Overview01:28

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
Synthetic Biology02:55

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
Transduction01:16

Transduction

Among the three main modes of HGT—transformation, conjugation, and transduction—transduction is unique in that it is mediated by bacteriophages, or bacterial viruses.Transduction occurs in two ways. Generalized transduction occurs during the lytic cycle of a bacteriophage infection. In this process, bacteriophages infect bacterial cells, replicate within them, and ultimately cause cell lysis, releasing newly assembled virions. Occasionally, random fragments of the bacterial genome are...
Upstream Processing01:27

Upstream Processing

Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2.

Nature communications·2025
Same author

Updated Labeling for Menopausal Hormone Therapy.

JAMA·2025
Same author

Functional and molecular single-cell analyses implicate PRDM14 in the initiation of B cell leukemia in mice.

Scientific reports·2025
Same author

Translating multiscale research in rare disease.

Disease models & mechanisms·2024
Same author

Functional exploration of copy number alterations in a Drosophila model of triple-negative breast cancer.

Disease models & mechanisms·2024
Same author

Sex matters in preclinical research.

Disease models & mechanisms·2024

Related Experiment Video

Updated: May 12, 2026

Working with Human Tissues for Translational Cancer Research
07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

Bridging the gap between basic and applied biology: towards preclinical translation.

Ross L Cagan, Monica J Justice, George F Tidmarsh

    Disease Models & Mechanisms
    |April 26, 2013
    PubMed
    Summary

    Disease Models & Mechanisms (DMM) is shifting focus from single genes to complex biological mechanisms. The journal will champion rigorous animal model assessment for improved preclinical drug development standards.

    More Related Videos

    Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
    10:19

    Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

    Published on: June 26, 2014

    Related Experiment Videos

    Last Updated: May 12, 2026

    Working with Human Tissues for Translational Cancer Research
    07:48

    Working with Human Tissues for Translational Cancer Research

    Published on: November 26, 2015

    Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery
    10:19

    Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery

    Published on: June 26, 2014

    Area of Science:

    • Biomedical Research
    • Translational Science
    • Genetics

    Background:

    • Traditional one-gene-one-phenotype models are insufficient for clinical translation.
    • Complex biological mechanisms are increasingly recognized as crucial for understanding disease.

    Discussion:

    • Disease Models & Mechanisms (DMM) will serve as a key platform for research bridging basic and applied science.
    • The journal emphasizes the critical role of rigorous assessment of animal models in disease research.

    Key Insights:

    • Transitioning from simple genetic models to complex mechanisms is essential for clinical translation.
    • Robust preclinical testing standards are vital for effective drug development.

    Outlook:

    • DMM aims to foster a deeper understanding of disease complexity.
    • The journal will drive the establishment of higher standards in preclinical research and drug discovery.