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Updated: May 12, 2026

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes

Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes

Published on: September 8, 2013

Iridium(I) hydroxides: powerful synthons for bond activation.

Byron J Truscott¹, David J Nelson, Cristina Lujan

¹EaStCHEM, School of Chemistry, University of St. Andrews, Purdie Building, North Haugh, St. Andrews, Fife KY16 9ST, UK.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|April 26, 2013

Summary

This summary is machine-generated.

New iridium(I) hydroxide complexes activate various chemical bonds under mild conditions. This atom-efficient method, producing only water as waste, offers potential for novel organic synthesis and small-molecule activation catalysis.

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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

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Published on: April 10, 2015

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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphos^Ph Complexes

Published on: April 10, 2015

Area of Science:

Organometallic Chemistry
Catalysis
Synthetic Chemistry

Background:

Iridium complexes are vital in catalysis.
Developing new ligands and metal complexes expands synthetic possibilities.
N-heterocyclic carbenes (NHCs) are versatile ligands in organometallic chemistry.

Purpose of the Study:

To synthesize and characterize a new family of iridium(I) hydroxide complexes.
To investigate the structural and steric properties of these complexes.
To explore the reactivity and catalytic potential of these iridium complexes in bond activation.

Main Methods:

Synthesis of iridium(I) hydroxide complexes of the form [Ir(cod)(NHC)(OH)].
Single-crystal X-ray diffraction for structural analysis.
Computational methods to study steric properties.
Reaction studies with various substrates including boronic acids, silicon compounds, alcohols, carboxylic acids, and amines.

Main Results:

A new family of iridium(I) hydroxide complexes, [Ir(cod)(NHC)(OH)], was successfully synthesized.
Structural and steric properties were elucidated using X-ray crystallography and computational analysis.
The model complex [Ir(cod)(IiPr)(OH)] demonstrated reactivity towards boronic acids, silicon compounds, and achieved O-H, N-H, and C-H bond activation.
Mild reaction conditions (room temperature) and high atom efficiency were observed, with water as the sole byproduct for X-H bond activation.

Conclusions:

The reported iridium(I) hydroxides represent a versatile synthon for chemical transformations.
These complexes enable the activation of important chemical bonds under mild, additive-free conditions.
The system holds significant promise for developing new catalytic cycles in organic synthesis and small-molecule activation.