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An 11-year-old boy with pharyngitis and cough: Lemierre syndrome
Patricia Mação1, Candida Cancelinha, Paulo Lopes
1Department of Emergency Service and Infectious Disease Unit, Hospital Pediátrico Coimbra, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal. patriciamacao@gmail.com
Insights
This case highlights Lemierre syndrome, a serious complication of pharyngitis. Early diagnosis and treatment of this rare condition are crucial to prevent severe outcomes.
Area of Science:
- Infectious Diseases
- Pediatrics
- Critical Care Medicine
Background:
- Pharyngitis is common in children, usually treated with antibiotics like amoxicillin.
- Complications can arise, necessitating a broader differential diagnosis when symptoms worsen.
Observation:
- An 11-year-old boy with pharyngitis developed worsening symptoms including cough, fever, lethargy, and respiratory distress.
- Clinical presentation evolved to include neck pain, a palpable neck mass, internal jugular vein thrombosis, and septic emboli.
Findings:
- Radiographic findings initially suggested pneumonia, but subsequent investigations revealed Lemierre syndrome.
- Diagnosis was confirmed by ultrasound and CT scans showing internal jugular vein thrombosis, parapharyngeal abscess, and septic pulmonary emboli.
Implications:
- This case underscores the importance of considering Lemierre syndrome in pediatric patients with pharyngitis and progressing symptoms.
- Prompt diagnosis and multidisciplinary management, including antibiotics and anticoagulation, are vital for favorable outcomes and preventing fatal complications.
Abstract:
The authors present the case of an 11-year-old boy with pharyngitis, treated with amoxicillin, that worsened on day 7, with cough, high fever and refusal to eat. Lethargy and respiratory distress were noted. Based on radiographic findings of bilateral infiltrates he was diagnosed with pneumonia and started on intravenous ampicillin and erythromycin. Two days later he complained of right-sided neck pain and a palpable mass was identified. An ultrasound showed partial thrombosis of the right internal jugular vein and a lung CT scan revealed multiple septic embolic lesions. Lemierre syndrome was diagnosed, antibiotic treatment adjusted and anticoagulation started. A neck CT-scan showed a large parapharyngeal abscess. His clinical condition improved gradually and after 3 weeks of intravenous antibiotics he was discharged home on oral treatment. This case illustrates the importance of diagnosing Lemierre syndrome in the presence of pharyngitis with localised neck pain and respiratory distress, to prevent potentially fatal complications.
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