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Retroperitoneal amyloidosis as the presenting manifestation of Waldenstrom's macroglobulinaemia

Domingo Franco-Palacios1, Maher Tama, Suprotim Samaddar

  • 1Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA. dfrancopalacios@gmail.com

BMJ Case Reports
|April 26, 2013
PubMed

Insights

Retroperitoneal amyloidosis, a rare condition, was diagnosed alongside Waldenstrom

Area of Science:

  • Oncology
  • Nephrology
  • Pathology

Background:

  • Retroperitoneal amyloidosis is infrequently reported, often linked to inflammation or malignancy.
  • Amyloidosis involves abnormal protein deposits in organs, potentially impairing function.

Observation:

  • A 69-year-old male presented with a significant pleural effusion and an incidentally discovered retroperitoneal mass on CT scan.
  • Diagnostic workup revealed amyloidosis affecting the retroperitoneum.

Findings:

  • The patient was diagnosed with concurrent Waldenstrom's macroglobulinaemia, a lymphoproliferative disorder.
  • Amyloid deposition was confirmed in the retroperitoneal tissues.

Implications:

  • Chemotherapy targeting both lymphoid and plasma cell components offers a potential treatment strategy for Waldenstrom's macroglobulinaemia.
  • This therapeutic approach may improve survival outcomes for affected patients.

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