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Neuronal hyperplasia in the anal canal
1Department of Pathology, Odense University Hospital, Denmark.
Histopathology
|May 1, 1990
Summary
Neuronal hyperplasia, an overgrowth of nerve cells and Schwann cells, was observed in anal canal tissues, particularly with hemorrhoids. This acquired condition may result from local mechanical factors.
Area of Science:
- Gastroenterology
- Surgical Pathology
- Neuroscience
Background:
- Neuronal hyperplasia, an increase in nerve cells, is a recognized pathological finding.
- Its presence in the anal canal, especially in relation to common conditions like hemorrhoids, requires further investigation.
Purpose of the Study:
- To investigate the occurrence and characteristics of neuronal hyperplasia in anal canal surgical specimens.
- To explore potential associations between anal neuronal hyperplasia and conditions such as hemorrhoids and fibrous polyps.
Main Methods:
- Histopathological examination of 56 hemorrhoidectomy specimens, 23 fibrous polyp specimens, and 14 anal canal resections.
- Immunohistochemical analysis of hyperplastic foci to identify cellular components and neurotransmitter expression.
Main Results:
- Neuronal hyperplasia was identified in 9/56 hemorrhoidectomy specimens and 4/23 fibrous polyps.
- Of 14 anal canal resections, 6 showed neuronal hyperplasia, with 5 of these cases also having hemorrhoids.
- Hyperplasia was consistently located in the submucosa beneath squamous epithelium, measuring 5-12 mm, and comprised neuronal and Schwann cells.
Conclusions:
- Anal neuronal hyperplasia is an acquired lesion, likely resulting from local mechanical influences.
- The presence of hemorrhoids appears to be associated with anal neuronal hyperplasia.