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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Updated: May 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Published on: September 30, 2021

CT-pathologic correlation in primary hepatocellular carcinoma: an implication for target delineation.

Hai-yan Chen1, Xiu-Mei Ma, Ming Ye

  • 1Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.

Journal of Radiation Research
|April 26, 2013
PubMed
Summary

Computed tomography (CT) size and gross pathologic size for hepatocellular carcinoma (HCC) are strongly correlated. CT scans often overestimate tumor size, but can guide radiation planning with appropriate margins.

Keywords:
CT-pathologic relationhepatocellular carcinomaradiationtarget delineation

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Last Updated: May 12, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software
07:32

Mast Cells in the Microenvironment of Hepatocellular Carcinoma Confer Favorable Prognosis: A Retrospective Study using QuPath Image Analysis Software

Published on: April 12, 2024

Area of Science:

  • Oncology
  • Radiology
  • Surgical Pathology

Background:

  • Accurate tumor size measurement is crucial for hepatocellular carcinoma (HCC) treatment planning.
  • Discrepancies between imaging and pathologic size can impact therapeutic decisions.

Purpose of the Study:

  • To analyze the correlation between computed tomography (CT) size and gross pathologic size in primary HCC.
  • To evaluate the accuracy of CT in estimating HCC tumor dimensions for surgical planning.

Main Methods:

  • Retrospective analysis of 174 HCC patients who underwent surgery.
  • Comparison of enhanced CT measurements (within 30 days pre-op) with post-resection gross pathologic measurements.
  • Statistical analysis including regression and percent size difference (%Δsize).

Main Results:

  • A strong positive correlation was found between radiographic and pathologic HCC size (r = 0.983, P < 0.001).
  • CT measurements overestimated tumor size by a median of 2.16 mm (P = 0.024), with 63.2% of tumors appearing larger or equal on CT.
  • Underestimation by CT was significant for tumors 3-5 cm, Grade I HCC, and those with clear boundaries.

Conclusions:

  • While CT and pathologic sizes of HCC are highly correlated, CT can overestimate dimensions.
  • Radiographic tumor size is valuable for radiation therapy planning, with specific margins recommended based on size.
  • Understanding CT size discrepancies is vital for optimizing treatment strategies in HCC.