Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Radiation: Applications

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...

Radiation Pressure: Problem Solving

Radiation Pressure: Problem Solving

The radiation pressure applied by an electromagnetic wave on a perfectly absorbing surface equals the energy density of the wave. The wave's momentum also gets transferred to the surface when an electromagnetic wave is entirely absorbed by it. The rate at which momentum is transmitted to an absorbing surface perpendicular to the propagation direction equals the force on the surface.
The average value of the rate of momentum transfer divided by the absorbing area represents the average force per...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analysis of an AI-powered system for vaccination screening, monitoring, and management in adults aged 50 and above.

Frontiers in public health·2026

Same author

A long-distance signaling loop promotes soybean nodulation and productivity.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Simultaneous determination of trimethylamine N-oxide (TMAO) and its 15 related metabolites by UPLC-MS/MS in human serum.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences·2026

Same author

Corrigendum to "Fucoidan alleviates chemotherapy-induced steatohepatitis by regulating the gut-liver axis" [Int. Immunopharmacol. 175 (2026) 116390].

International immunopharmacology·2026

Same author

Development of a Sensitive UPLC-MS/MS Method for the Simultaneous Quantification of Mycotoxins in Wheat Products and Human Urine.

Toxins·2026

Same author

Deciphering the role of tubulin's C-terminal tail in kinesin binding using computational and clustering approaches.

Scientific reports·2026

Same journal

Bridging Global Attention and Local Hierarchies: A Robust Hybrid Ensemble Framework With Multi-Perspective Explainability for Automated HER2-IHC Scoring.

Technology in cancer research & treatment·2026

Same journal

Research on Predicting the Efficacy of Immunotherapy for Non-small Cell Lung Cancer Based on CT Radiomics and Peripheral Blood Inflammatory Markers.

Technology in cancer research & treatment·2026

Same journal

Survival Prediction in Patients With Epidermal Growth Factor Receptor-Mutated Non-small Cell Lung Cancer With Bone Metastases Receiving Icotinib Therapy: A Retrospective Observational Study.

Technology in cancer research & treatment·2026

Same journal

Proteomics in Acute Myeloid Leukemia: Current Applications in Precision Medicine and Targeted Immunotherapy.

Technology in cancer research & treatment·2026

Same journal

EML4-ALK in Non-small Cell Lung Cancer: Molecular Mechanisms and Targeted Therapies.

Technology in cancer research & treatment·2026

Same journal

Developing and Validating a Risk Model for Severe Bone Marrow Suppression in Esophageal Cancer Treated with Radiotherapy or Chemoradiotherapy: A Retrospective Cohort Study.

Technology in cancer research & treatment·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Inverse planning optimization method for intensity modulated radiation therapy.

Yihua Lan¹, Haozheng Ren, Cunhua Li

¹School of Computer and Information Technology, Nanyang Normal University, Nanyang, Henan 473061, P.R.China. Cchung2012@sina.com.

Technology in Cancer Research & Treatment

|April 27, 2013

Summary

This summary is machine-generated.

Smoothing planned fluence maps is crucial for intensity modulated radiation therapy (IMRT) leaf sequencing. This study introduces a novel method balancing dose conformity and monitor units for improved treatment precision.

More Related Videos

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Related Experiment Videos

Last Updated: May 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources

Published on: October 6, 2023

Area of Science:

Medical Physics
Radiation Oncology
Computational Imaging

Background:

Leaf sequencing in Intensity Modulated Radiation Therapy (IMRT) requires smoothed planned fluence maps for efficient and precise dose delivery.
Existing smoothing models may not optimally balance dose conformity and the total number of monitor units (TNMU).

Purpose of the Study:

To develop and evaluate a novel fluence map smoothing model for IMRT leaf sequencing.
To optimize the balance between dose distribution conformity and the total number of monitor units (TNMU).

Main Methods:

Formulated a fluence map optimization model incorporating the maximum flow value of horizontal paths in a digraph representation.
The model is a linear constrained quadratic optimization problem, solvable by the interior point method.
Compared the proposed model against a total variance-based smoothing model using clinical head-neck and prostate cases.

Main Results:

The proposed model achieved significantly better dose performance in target and non-target regions compared to the total variance model at similar TNMU levels.
Demonstrated a good balance between dose conformity and TNMU, indicating improved treatment planning efficiency and precision.
Smoothed fluence maps generated by the model are more suitable for practical leaf sequencing algorithms.

Conclusions:

The proposed fluence map smoothing method effectively balances dose conformity and TNMU, enhancing IMRT treatment planning.
This approach offers a promising strategy for improving the efficiency and precision of leaf sequencing algorithms.
The methodology can be extended to other fluence map optimization models for broader applicability in radiation therapy.