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Published on: April 7, 2023
Hemodynamic analysis in infants with late-onset circulatory collapse
Yosuke Washio1, Atsushi Uchiyama, Hidehiko Nakanishi
1Department of Neonatology, Maternal and Perinatal Center, Tokyo Women's Medical University, Tokyo, Japan.
Summary
Late-onset circulatory collapse (LCC) in preterm infants presents as distributive shock with a hyperdynamic state. Echography reveals altered organ blood flow, indicating LCC
Area of Science:
- Neonatal Physiology
- Pediatric Cardiology
- Hemodynamics
Background:
- Late-onset circulatory collapse (LCC) affects preterm infants post-acute stage.
- Characterized by sudden hypotension and oliguria without clear causes.
- Echography is used to assess hemodynamic changes in LCC.
Purpose of the Study:
- To investigate hemodynamic changes during LCC.
- To correlate myocardial function with organ blood flow using echography.
Main Methods:
- Prospective echographic study of 7 very-low-birthweight infants with LCC.
- Comparison with 8 matched control infants.
- Echographic assessment at multiple time points: before, during, and after LCC.
Main Results:
- Increased ejection fraction and decreased end-systolic wall stress in LCC infants.
- Increased superior mesenteric artery flow velocity.
- Decreased anterior cerebral artery flow velocity, maintained renal artery flow velocity.
Conclusions:
- LCC is a distributive shock with a hyperdynamic state and reduced afterload.
- Echographic organ flow analysis aids in understanding LCC pathophysiology.
