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Alteration of pulmonary function in diabetic nephropathy
Gita Shafiee1, Mohammad E Khamseh, Nader Rezaei
1Endocrine Research Center (Firouzgar), Institute of Endocrinology and Metabolism, Tehran University of Medical Sciences, Karimkhan St, Tehran 1593748711, Iran. malekmoj@tums.ac.ir.
Journal of Diabetes and Metabolic Disorders
|April 27, 2013
Summary
Pulmonary function is impaired in people with type 2 diabetes, especially with advancing diabetic nephropathy. This study highlights the link between kidney complications and reduced lung capacity in diabetic patients.
Area of Science:
- Endocrinology
- Pulmonology
- Nephrology
Background:
- Type 2 diabetes mellitus (T2DM) is a growing global health concern.
- T2DM is linked to numerous chronic complications, including kidney disease.
- Pulmonary function alterations and their association with nephropathy in T2DM require further investigation.
Purpose of the Study:
- To investigate changes in pulmonary function among individuals with T2DM.
- To explore the relationship between diabetic nephropathy and pulmonary function.
- To compare pulmonary function across different stages of diabetic nephropathy.
Main Methods:
- A cross-sectional study involving 120 participants: 40 diabetic without nephropathy, 40 with nephropathy, and 40 healthy controls.
- Participants with nephropathy were categorized into microalbuminuria and macroalbuminuria groups.
- Pulmonary function tests (spirometry) were conducted, measuring Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and Peak Expiratory Flow (PEF).
Main Results:
- Diabetic nephropathy significantly reduced FVC, FEV1, and PEF compared to healthy controls.
- Diabetic individuals with nephropathy exhibited lower FVC and FEV1 than those with normal albumin excretion.
- FEV1/FVC ratio was elevated in diabetic individuals with nephropathy.
- Significant differences in FVC and FEV1 were noted between microalbuminuria and macroalbuminuria groups.
Conclusions:
- Pulmonary function is demonstrably impaired in individuals with diabetes.
- The severity of pulmonary function impairment correlates with the progression of diabetic nephropathy.
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