Circulating adhesion molecules in obstructive sleep apnea and cardiovascular disease
Victoria M Pak1, Michael A Grandner2, Allan I Pack2
1Center for Sleep and Circadian Neurobiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Biobehavioral Health Sciences, University of Pennsylvania School of Nursing, Philadelphia, PA, USA.
Sleep Medicine Reviews
|April 27, 2013
Summary
Obstructive sleep apnea (OSA) is linked to cardiovascular disease, potentially through inflammation and adhesion molecules. Treating OSA may reduce these molecules, offering a therapeutic target for cardiovascular risk.
Area of Science:
- Cardiovascular Medicine
- Sleep Medicine
- Immunology
Background:
- Obstructive sleep apnea (OSA) is strongly associated with cardiovascular disease (CVD).
- Inflammatory processes are implicated in the OSA-CVD link, but mechanisms remain unclear.
- Atherosclerosis is a potential mechanism connecting OSA to cardiovascular morbidity.
Purpose of the Study:
- To review the role of circulating adhesion molecules in patients with OSA.
- To explore how adhesion molecules may link OSA to cardiovascular disease.
- To identify potential therapeutic strategies targeting adhesion molecules in OSA.
Main Methods:
- Literature review of studies investigating adhesion molecules in OSA and CVD.
- Analysis of evidence linking adhesion molecules to cardiovascular disease risk.
- Examination of studies on adhesion molecule levels in OSA patients and the effect of continuous positive airway pressure (CPAP) therapy.
Main Results:
- Adhesion molecules play a role in cardiovascular disease risk.
- Some studies show elevated adhesion molecule levels in OSA patients compared to controls.
- CPAP therapy may reduce adhesion molecule levels in OSA patients.
Conclusions:
- Circulating adhesion molecules represent a potential mechanistic link between OSA and cardiovascular disease.
- Further research is needed to overcome limitations such as small sample sizes and confounding variables.
- Targeting adhesion molecules may offer novel therapeutic approaches to reduce cardiovascular disease in OSA patients.
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