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Related Concept Videos

Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Related Experiment Video

Updated: May 12, 2026

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation
11:40

Retroviral Infection of Murine Embryonic Stem Cell Derived Embryoid Body Cells for Analysis of Hematopoietic Differentiation

Published on: October 20, 2014

Signalling pathways that control vertebrate haematopoietic stem cell specification.

Wilson K Clements1, David Traver

  • 1Department of Hematology, Division of Experimental Hematology, St Jude Children's Research Hospital, 262 Danny Thomas Pl., Memphis, Tennessee 38105, USA.

Nature Reviews. Immunology
|April 27, 2013
PubMed
Summary

Haematopoietic stem cells (HSCs) are crucial for blood formation and transplantation. New research reveals previously unknown signalling pathways and gene expression in somites essential for specifying HSCs during embryonic development.

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Last Updated: May 12, 2026

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14:37

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Published on: November 1, 2017

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Hematopoiesis

Background:

  • Haematopoietic stem cells (HSCs) are vital for lifelong blood cell replenishment and form the basis of transplantation therapies for blood disorders.
  • Understanding embryonic HSC specification is key to generating transplantable HSCs in vitro.

Purpose of the Study:

  • To review current knowledge on intraembryonic signals regulating HSC specification in vertebrates.
  • To highlight recent discoveries regarding signalling requirements and somite gene expression in HSC development.

Main Methods:

  • Review of recent embryological studies.
  • Analysis of signalling pathways involved in haemogenic fate transition.

Main Results:

  • Identification of previously unknown signalling requirements for HSC specification.
  • Demonstration of the integral role of somite gene expression in regulating the endothelial-to-haemogenic transition.

Conclusions:

  • Intraembryonic signals and somite gene expression are critical for specifying HSCs.
  • Further understanding of these mechanisms may enable in vitro generation of HSCs for therapeutic applications.