Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of Erythrocytes

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...

Multiple Allele Traits

Multiple Allele Traits

The Concept of Multiple Allelism

Lifecycle of Erythrocytes

Lifecycle of Erythrocytes

Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups.

Hypersensitivity Reactions: Cytolytic Reactions

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...

Changes in Skin Color: Clinical Perspectives

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...

Hemoglobin

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Analysis of 478 Revision Cases for Cervical Disc Arthroplasty Based on Their Biomechanical Design.

International journal of spine surgery·2026

Same author

Robotic-Assisted Muscle-Preserving (RAMP) Decompression in the Thoracic and Lumbar Spine: A Cadaveric Validation.

Spine·2026

Same author

A Structured Ultrasound-Guided Workflow for Level Identification in Lumbar Spine Surgery.

Spine·2026

Same author

Evaluating the Learning Curve and Surgical Efficacy in the Novel Robotic-Assisted Muscle-Preserving (RAMP) Spinal Decompression.

Global spine journal·2025

Same author

Perspectives of Spanish-Speaking Families on RSV Immunoprophylaxis for Healthy Newborns.

Journal of immigrant and minority health·2025

Same author

Is Intraoperative Neuromonitoring with SSEPs and EMG Predictable for Postoperative Neurologic Deficit in Posterior Lumbar Fusion Surgery? A Retrospective Cohort Analysis.

Global spine journal·2025

Same journal

Increased 18F-FDG Avidity on PET/CT During Treatment for Rhabdomyosarcoma Confirmed to Be Mature Rhabdomyoblasts.

Journal of pediatric hematology/oncology·2026

Same journal

Assessment of Immunization Status Following Non-HSCT Chemotherapy-treated Pediatric Leukemia Survivors.

Journal of pediatric hematology/oncology·2026

Same journal

Frequent Use of Hematologic Testing in Children Admitted for Nonaccidental Trauma.

Journal of pediatric hematology/oncology·2026

Same journal

Unresponsive Systemic Mastocytosis in a Young AML With RUNX1::RUNX1T1 Fusion With Rare KIT c.1255_1257delGAC Mutation: A Clinical Deadlock.

Journal of pediatric hematology/oncology·2026

Same journal

Local Control and Survival Outcomes in Pediatric Nonrhabdomyosarcoma Soft Tissue Sarcoma: The Mayo Clinic Experience.

Journal of pediatric hematology/oncology·2026

Same journal

Diagnostic Pitfalls in Pediatric Acute Promyelocytic Leukemia: All-trans Retinoic Acid-Associated Hypercalcemia Mimicking Fungal Meningitis and the Risks of Azole Coadministration.

Journal of pediatric hematology/oncology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 11, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Hyperhemolysis in sickle cell disease.

Elena Aragona¹, Michael J Kelly

¹*Division of Hospitalist Medicine, Children's National Medical Center, The George Washington University School of Medicine and Health Sciences, Washington, DC †Division of Pediatric Hematology Oncology, The Floating Hospital for Children at Tufts Medical Center, Tufts University School of Medicine, Boston, MA.

Journal of Pediatric Hematology/Oncology

|April 27, 2013

Summary

This summary is machine-generated.

Sickle cell disease patients experiencing hemolysis after blood transfusions may have hyperhemolysis. Prompt diagnosis and treatment are crucial to prevent life-threatening anemia from accelerated hemolysis.

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Hematology
Transfusion Medicine
Sickle Cell Disease

Background:

Sickle cell disease (SCD) patients are at risk for various complications, including hemolytic reactions following blood transfusions.
Hyperhemolysis is a rare but severe complication characterized by excessive red blood cell destruction.
Distinguishing hyperhemolysis from other transfusion reactions is critical for appropriate management.

Observation:

An 18-year-old female with SCD presented with symptoms of hemolysis (thigh pain, dark urine, hematuria) post-transfusion.
Laboratory findings revealed reticulocytopenia, inconsistent with typical antibody-mediated transfusion reactions.

Findings:

The patient was diagnosed with hyperhemolysis, a rare complication characterized by accelerated red blood cell destruction.
Treatment with intravenous immunoglobulin (IVIG) and steroids was initiated for presumed hyperhemolysis.

Implications:

Clinicians must maintain a high index of suspicion for hyperhemolysis in SCD patients with post-transfusion hemolysis.
Prompt differentiation from other hemolytic syndromes is vital, as further transfusions can exacerbate hemolysis and lead to severe anemia.