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Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...

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Updated: May 11, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

[Puberty, fertility and chronic diseases].

A Thébaut¹, M Amouyal, A Besançon

¹Service d'endocrinologie et diabétologie de l'enfant, université Paris 11, hôpital Bicêtre Paris-Sud, AP-HP, 78, avenue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|April 27, 2013

Summary

Chronic diseases and medications significantly impact pubertal development and reproductive health by affecting hormonal regulation and fat mass. Careful monitoring is crucial for managing pubertal delay and its consequences in adolescents with chronic conditions.

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Area of Science:

Endocrinology
Reproductive Medicine
Pediatrics

Context:

Pubertal development is a complex process influenced by numerous factors, including hormonal signaling and metabolic status.
Chronic diseases can disrupt the intricate mechanisms governing puberty onset and progression.
The hypothalamus plays a central role in relaying signals related to fat mass to regulate reproductive function.

Purpose:

To explore how chronic diseases, such as cystic fibrosis and chronic renal disease, impact pubertal development and fertility.
To examine the effects of medications, including corticosteroids and chemotherapy, on reproductive health.
To outline strategies for surveillance and care of pubertal delay in adolescents with chronic disorders.

Summary:

Puberty involves complex hormonal and metabolic interactions, with fat mass and hypothalamic signaling being key regulators.
Chronic illnesses like cystic fibrosis and chronic renal disease can impair gonadal maturation and reproductive capacity through distinct pathways.
Medications such as corticosteroids and chemotherapy also pose risks to reproductive function, necessitating careful management.

Impact:

Understanding these disruptions is vital for optimizing reproductive health outcomes in affected individuals.
This review highlights the importance of addressing growth and bone mineralization alongside pubertal delay.
Provides a framework for comprehensive care of adolescents experiencing pubertal challenges due to chronic conditions.