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Related Experiment Video

Updated: May 11, 2026

Performing Repeated Intraoperative Impedance Telemetry Measurements during Cochlear Implantation
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Published on: August 4, 2023

Longitudinal impedance variability in patients with chronically implanted DBS devices.

Tyler Cheung1, Miriam Nuño, Matilde Hoffman

  • 1Department of Neurology, Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians E-238, Los Angeles, CA 90048, USA.

Brain Stimulation
|April 27, 2013
PubMed
Summary
This summary is machine-generated.

Impedance variability is common in chronically implanted deep brain stimulation (DBS) electrodes for movement disorders. Factors like time and electrode position significantly influence these impedance trends, impacting DBS therapy delivery.

Keywords:
Deep brain stimulationGlobus pallidusImpedanceMovement disordersSubthalamic nucleus

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Last Updated: May 11, 2026

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Area of Science:

  • Neurosurgery
  • Biomedical Engineering
  • Neurology

Background:

  • Deep brain stimulation (DBS) is a key therapy for advanced movement disorders.
  • Optimal DBS therapy delivery may be affected by electrode-tissue interface impedance variability.

Purpose of the Study:

  • To analyze impedance variability and trends in chronically implanted DBS electrodes.
  • Identify factors influencing impedance in patients with movement disorders.

Main Methods:

  • Retrospective review of impedance data from 94 DBS patients.
  • Calculated longitudinal impedance variability using standard deviation.
  • Employed a generalized linear mixed model (GLMM) to assess predictor influences.

Main Results:

  • Analyzed 2863 impedance measurements over 5 years.
  • Median subject impedance variability was 194 Ω, and contact variability was 141 Ω.
  • Significant predictors of impedance included time, electrical activity, target, contact position, and implantation side.

Conclusions:

  • Significant impedance variability is expected in chronically implanted DBS electrodes.
  • Several factors can predict impedance characteristics.
  • Further research is needed to correlate impedance with clinical outcomes.