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Related Concept Videos

Uterine Tubes01:16

Uterine Tubes

The uterine or fallopian tubes function as the conduit through which oocytes travel from the ovaries to the uterus. Each fallopian tube measures approximately 10 to 13 cm long and is anatomically divided into the infundibulum, ampulla, isthmus, and interstitial part (or intramural segment). The infundibulum is characterized by its funnel shape and features extensions called fimbriae which reach towards the peritoneal cavity. These fimbriae play a critical role during ovulation as they extend...
Exocrine Glands: Unicellular and Multicellular Glands01:29

Exocrine Glands: Unicellular and Multicellular Glands

Exocrine glands are classified as unicellular and multicellular. The unicellular glands are scattered single cells, such as goblet cells, found in the mucous membranes of the small and large intestines. On the other hand, multicellular exocrine glands develop as secretory sheets, like the internal lining of the abdomen or chest. Such secretory sheets release their secretions directly into the lumen of these organs. In addition, some multicellular glands have deep-seated secretory units to...
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...
Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine glands...
Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...

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Establishing 3D Endometrial Organoids from the Mouse Uterus
06:24

Establishing 3D Endometrial Organoids from the Mouse Uterus

Published on: January 6, 2023

Uterine glands: development, function and experimental model systems.

Paul S Cooke1, Thomas E Spencer, Frank F Bartol

  • 1Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA. paulscooke@ufl.edu

Molecular Human Reproduction
|April 27, 2013
PubMed
Summary
This summary is machine-generated.

Neonatal progestin treatment inhibits uterine gland development, causing permanent infertility in mammals. This finding suggests a potential contraceptive strategy applicable across species, including dogs.

Keywords:
adenogenesiscontraceptionendometriummurineungulate

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Area of Science:

  • Reproductive Biology
  • Developmental Biology
  • Endocrinology

Background:

  • Uterine gland development (adenogenesis) is crucial for mammalian pregnancy, initiating post-natally via epithelial budding and proliferation.
  • Inhibiting adenogenesis through genetic or epigenetic means leads to infertility, highlighting the glands' essential role.
  • Key genes like FOXA2, beta-catenin, Wnt, and Hox are involved in uterine gland formation.

Purpose of the Study:

  • To investigate the impact of neonatal progestin exposure on uterine adenogenesis and fertility.
  • To explore the potential of progestin treatment as a contraceptive strategy.
  • To understand the molecular mechanisms of endometrial development and function.

Main Methods:

  • Utilizing progestin treatment in neonatal sheep and mice to create models of infertility.
  • Analyzing the effects of neonatal progestin exposure on uterine gland development and endometrial structure.
  • Investigating the temporal patterns of adenogenesis in juvenile dogs.

Main Results:

  • Neonatal progestin treatment in sheep and mice resulted in permanent infertility due to impaired adenogenesis.
  • A critical developmental window was identified where progestin treatment induced lasting infertility and implantation defects.
  • Studies in dogs are exploring steroid hormone treatments for contraceptive potential.

Conclusions:

  • Neonatal progestin exposure permanently disrupts uterine gland development and fertility.
  • This disruption mechanism offers a potential contraceptive strategy for various species.
  • Further research in dogs aims to validate steroid hormone-based contraception.