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Updated: May 11, 2026

Quantification of Hypopigmentation Activity In Vitro
Published on: March 6, 2019
Clinicopathological correlation of acquired hypopigmentary disorders
Anisha B Patel1, Raj Kubba, Asha Kubba
1Department of Dermatology, Oregon Health Sciences University, Portland, Oregon, USA.
Abstract:
Acquired hypopigmentary disorders comprise a significant group of disorders that affect Indians and Asians. The pigment disturbance in darker skin individuals can be very distressing to the patient and the family. These disorders cover a wide array of pathologies including infections, autoimmune processes, lymphoproliferative disorders, and sclerosing diseases. Histological diagnosis is particularly important because treatments for these diseases are varied and specific. This review will focus on histopathological diagnosis based on clinicopathological correlation for commonly encountered disorders such as leprosy, vitiligo, lichen sclerosus, pityriasis alba (PA), and pityriasis versicolor (PV). Atypical or uncommon clinical presentation of classic diseases such as hypopigmented mycosis fungoides (HMF) and hypopigmented sarcoidosis are also included.
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