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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...

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Related Experiment Video

Updated: May 11, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

The bioartificial kidney: current status and future promise.

H David Humes1, Deborah Buffington, Angela J Westover

  • 1Innovative BioTherapies, Inc., 650 Avis Dr., Suite 300, Ann Arbor, MI, 48108, USA, dhumes@med.umich.edu.

Pediatric Nephrology (Berlin, Germany)
|April 27, 2013
PubMed
Summary

New cell therapy and tissue engineering technologies are creating a bioartificial kidney to treat kidney failure. This wearable or implantable device aims to restore kidney function, reducing complications for patients with acute or chronic kidney disease.

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Murine Kidney Transplant Technique
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Last Updated: May 11, 2026

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nephrology

Background:

  • Understanding cellular and molecular mechanisms of kidney function and disease is advancing rapidly.
  • Acute and chronic renal failure represent significant clinical challenges with limited therapeutic options.
  • Cell therapy and tissue engineering offer novel approaches for treating organ dysfunction.

Purpose of the Study:

  • To review the current development status of wearable or implantable bioartificial kidneys.
  • To highlight the potential of cell therapy and tissue engineering in renal replacement therapy.
  • To discuss the promise of these technologies in diminishing morbidity and mortality in kidney disease patients.

Main Methods:

  • Development of cell therapy devices to replace kidney functions (filtration, metabolism, endocrinology).
  • Expansion of stem or progenitor cells in tissue culture for differentiated tasks.
  • Introduction of engineered cells via extracorporeal circuits or implantable constructs.

Main Results:

  • Cell therapy devices are under development to mimic native kidney functions.
  • Bioartificial kidney devices are being designed for wearable or implantable applications.
  • The combination of these devices holds promise for full renal replacement therapy.

Conclusions:

  • Cell therapy and tissue engineering are pivotal for future kidney disease treatments.
  • Bioartificial kidneys offer a potential solution for renal replacement therapy.
  • These advanced technologies may significantly improve outcomes for patients with kidney failure.