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Updated: May 11, 2026
05:01
A Pathway Association Study Tool for GWAS Analyses of Metabolic Pathway Information
Published on: July 1, 2020
Family-based association mapping in crop species
Baohong Guo1, Daolong Wang, Zhigang Guo
1Syngenta Biotechnology Inc, 2369 330th Street, Slater, IA 50244, USA. baohong.guo@syngenta.com
Summary
Family-based association mapping (FBAM) can identify genetic variants for complex traits in crops. This powerful method uses advanced sequencing and breeding designs for efficient allele discovery.
Area of Science:
- Plant genetics
- Quantitative genetics
- Genomic selection
Background:
- Identifying genetic variants for complex traits is crucial for crop improvement.
- Family-based association mapping (FBAM) offers higher power and resolution than traditional methods.
Purpose of the Study:
- To explore the adaptation of human family-based association tests for crop species.
- To leverage next-generation sequencing for enhanced genetic analysis in plants.
Main Methods:
- Discusses the adaptation of human family-based association tests and quantitative transmission disequilibrium tests.
- Highlights the role of next-generation sequencing in genotyping parents and imputing progeny.
Main Results:
- FBAM can utilize linkage disequilibrium in segregating progeny and parents.
- Next-generation sequencing facilitates comprehensive genotyping for FBAM in crop breeding designs.
Conclusions:
- FBAM is a promising approach for discovering alleles underlying complex traits in crops.
- The integration of advanced sequencing technologies will accelerate the adoption of FBAM in plant breeding.
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