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DIALIGN at GOBICS--multiple sequence alignment using various sources of external information
Layal Al Ait1, Zaher Yamak, Burkhard Morgenstern
1Department of Bioinformatics, University of Göttingen, Institute of Microbiology and Genetics, Goldschmidtstr. 1, 37077 Göttingen, Germany.
Nucleic Acids Research
|April 27, 2013
Summary
DIALIGN is a multiple sequence alignment tool for detecting local homologies. A new version, DIALIGN-PFAM, improves protein alignment using PFAM database hits.
Area of Science:
- Bioinformatics
- Computational Biology
- Genomics
Background:
- DIALIGN is a well-established tool for multiple sequence alignment, excelling at identifying local homologies in sequences with low similarity.
- Recent advancements have led to diverse DIALIGN versions, including automated and user-guided implementations.
Purpose of the Study:
- To review available DIALIGN versions on the Göttingen Bioinformatics Compute Server.
- To introduce DIALIGN-PFAM, a novel release enhancing protein alignment through PFAM database integration.
Main Methods:
- Review of existing DIALIGN implementations.
- Development and integration of DIALIGN-PFAM utilizing PFAM database alignments.
- Software accessibility via the Göttingen Bioinformatics Compute Server.
Main Results:
- Several DIALIGN versions are accessible through the Göttingen Bioinformatics Compute Server.
- DIALIGN-PFAM demonstrates improved protein alignment by incorporating PFAM database information.
Conclusions:
- DIALIGN continues to evolve as a valuable tool for sequence analysis.
- DIALIGN-PFAM offers enhanced capabilities for protein alignment, particularly when leveraging PFAM data.
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