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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

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Related Experiment Video

Updated: May 11, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Genetics of ischaemic stroke.

Pankaj Sharma1, Sunaina Yadav, James F Meschia

  • 1Imperial College Cerebrovascular Research Unit (ICCRU), Imperial College London, , London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|April 27, 2013
PubMed
Summary

Genomic and computational advances are revealing the genetic basis of stroke. This knowledge is poised to change clinical practice for monogenic stroke and improve patient care.

Area of Science:

  • Genomics
  • Statistical Computation
  • Molecular Biology

Background:

  • Recent progress in genomics and computational statistics enables molecular-level investigation of stroke's genetic underpinnings.
  • Understanding the genetic basis of stroke is crucial for advancing clinical practice.

Purpose of the Study:

  • To review the current state of knowledge in ischemic stroke genetics.
  • To provide guidance for practicing clinicians on utilizing genetic insights in patient care.

Main Methods:

  • Literature review of recent advances in genomics and statistical computation related to stroke.
  • Synthesis of current knowledge on the genetic basis of ischemic stroke.

Main Results:

  • Genomic and computational advances are facilitating a deeper understanding of stroke genetics.
Keywords:
CEREBROVASCULARCEREBROVASCULAR DISEASEGENETICSSTROKE

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Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

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A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
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A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

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Related Experiment Videos

Last Updated: May 11, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

  • This evolving knowledge is expected to significantly impact the clinical management of certain monogenic stroke types.

    • Conclusions:

    • The integration of genetic information holds promise for revolutionizing stroke patient care.
    • Clinicians can leverage current genetic knowledge to improve diagnosis and treatment strategies for ischemic stroke.