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Published on: November 28, 2025
Reduced joint assessment vs comprehensive assessment for ultrasound detection of synovitis in juvenile idiopathic
Paz Collado1, Esperanza Naredo, Cristina Calvo
1Department of Rheumatology, Pediatric Rheumatology Unit, Severo Ochoa University Hospital, Av. Orellana s/n. 28910 Madrid, Spain. paxcollado@yahoo.es
Insights
A simplified 10-joint power Doppler ultrasound (PDUS) assessment effectively evaluates synovitis in juvenile idiopathic arthritis (JIA). This reduced PDUS method is valid, feasible, and reliable for clinical practice.
Area of Science:
- Pediatric Rheumatology
- Musculoskeletal Ultrasound
- Inflammatory Arthritis
Background:
- Juvenile idiopathic arthritis (JIA) requires accurate assessment of synovitis.
- Current comprehensive ultrasound assessments can be time-consuming.
- A validated, reduced joint assessment is needed for efficient clinical evaluation.
Purpose of the Study:
- To propose and validate a reduced joint power Doppler ultrasound (PDUS) assessment for synovitis in JIA.
- To compare its feasibility, reliability, and sensitivity to change against a comprehensive 44-joint PDUS assessment.
Main Methods:
- A multicentre study involving 42 children with active JIA.
- Blinded clinical and PDUS assessments of joints using greyscale (GS) and power Doppler.
- Development of a reduced 10-joint PDUS assessment based on joint involvement frequency.
Main Results:
- The 10-joint PDUS assessment identified 100% of children with synovitis.
- High correlation between the reduced and comprehensive PDUS assessments.
- The reduced model demonstrated superior responsiveness to change with good intra- and interobserver agreement.
Conclusions:
- The 10-joint PDUS assessment is a valid and feasible tool for evaluating synovitis in JIA.
- This reduced approach offers a practical alternative for clinical settings.
Objective:
To propose a reduced joint power Doppler US (PDUS) assessment and provide preliminary evidence of its validity, feasibility, reliability and sensitivity to change compared with a comprehensive (i.e. 44 joints) PDUS assessment in evaluating synovitis in JIA.
Methods:
This multicentre study included 42 children with active JIA with ≥4 clinically involved joints requiring modified therapy. At each visit, clinical and PDUS assessments were performed blinded. Each joint was scored for greyscale (GS) synovitis and power Doppler signal according to a 4-point semiquantitative scale with calculation of US composite indices and US composite joint counts. A process of data reduction based on the frequency of US joint involvement was performed to obtain a reduced PDUS assessment. The relationship between the comprehensive and the reduced PDUS assessments was investigated by Spearman's coefficient at all visits, as well as the relationship between changes in the two PDUS assessments during follow-up. In addition, the metric properties of the comprehensive and the reduced PDUS assessments were tested.
Results:
The 10-joint PDUS assessment, including bilateral knee, ankle, wrist, elbow and the second MCP joints, detected 100% of children with GS synovitis and power Doppler signal. The two PDUS assessments were highly correlated at all visits. The reduced model had a higher responsiveness than the comprehensive model. Intraobserver and interobserver agreement was good for both US findings.
Conclusion:
The 10-joint PDUS assessment is valid and feasible for assessment of synovitis in JIA in clinical practice.
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