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Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
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Presenting ADAMTS13 on a TTP-associated MHC

Kathleen P Pratt1

  • 1Puget Sound Blood Center Research Institute

Blood
|April 27, 2013
PubMed

In this issue of Blood, Sorvillo et al investigate possible molecular triggers leading to idiopathic, autoimmune thrombotic thrombocytopenic purpura (TTP) by identifying naturally processed A Disintegrin And Metalloprotease with ThromboSpondin type 1 motif 13 (ADAMTS13)-derived peptides presented on human dendritic cells.

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