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Related Concept Videos

Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also promote...
Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...

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Related Experiment Video

Updated: May 11, 2026

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Revisiting physiologic and psychologic triggers that increase spasticity.

Chetan P Phadke1, Chitralakshmi K Balasubramanian, Farooq Ismail

  • 1Upper Motorneuron Spasticity Research Program, West Park Healthcare Centre, Toronto, Canada.

American Journal of Physical Medicine & Rehabilitation
|April 27, 2013
PubMed
Summary

Physiologic and psychologic triggers can influence spasticity. Objective measures confirm triggers like pregnancy and cold, while self-reports suggest stress and clothing tightness also increase spasticity.

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy
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Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy

Published on: August 9, 2024

Area of Science:

  • Neurology
  • Rehabilitation Medicine

Background:

  • Spasticity is a common symptom in neurological disorders.
  • Identifying triggers is crucial for managing spasticity.

Purpose of the Study:

  • To systematically review literature on physiologic and psychologic triggers of spasticity.
  • To evaluate the evidence supporting various spasticity triggers.

Main Methods:

  • Literature search of PubMed, EMBASE, CINAHL, and PEDro databases.
  • Inclusion of studies using clinical tests or self-reports for spasticity assessment.
  • Review of 24 relevant articles from 1152 initially scanned.

Main Results:

  • Objective clinical tests confirmed increased spasticity with pregnancy, posture, cold, circadian rhythm, and skin conditions.
  • Self-reports indicated bowel/bladder issues, menstrual cycle, stress, and tight clothing as potential triggers.
  • No evidence found linking heterotopic ossification, hemorrhoids, DVT, fever, or sleep patterns to increased spasticity.

Conclusions:

  • Self-reported triggers suggest significant spasticity increases, but objective evidence is often lacking.
  • The effects of many triggers remain inconclusive without objective validation.
  • Findings primarily from spinal cord injury population; generalizability to other neurological conditions is unknown.