Related Experiment Video
Updated: May 11, 2026

Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy
Published on: September 9, 2020
Surgical treatment of hypertrophic cardiomyopathy
Sameh M Said1, Joseph A Dearani, Steve R Ommen
1Division of Cardiovascular Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Insights
Hypertrophic cardiomyopathy (HCM) is a genetic heart muscle disease. Septal myectomy surgery offers an excellent treatment option for patients with HCM who are intolerant or unresponsive to medical therapy.
Area of Science:
- Cardiology
- Genetics
- Cardiac Surgery
Background:
- Hypertrophic cardiomyopathy (HCM) is a primary myocardial disease causing unexplained left ventricular hypertrophy.
- It presents diversely, from asymptomatic cases to sudden cardiac death, and has a genetic basis.
- HCM variants include basal, midventricular, apical, and diffuse types.
Purpose of the Study:
- To review the current surgical treatment and outcomes of septal myectomy in hypertrophic cardiomyopathy.
- To discuss the role of surgery in managing different variants of HCM.
Main Methods:
- This is a review article summarizing existing literature on surgical treatment for HCM.
- Focus is on septal myectomy outcomes and its place in HCM management.
Main Results:
- Septal myectomy is an effective surgical option for HCM patients.
- It is particularly beneficial for individuals unresponsive or intolerant to medical management.
- The review covers surgical outcomes across different HCM variants.
Conclusions:
- Septal myectomy remains a crucial intervention for specific HCM patient populations.
- Understanding HCM variants is essential for tailoring surgical approaches.
- Surgery provides a valuable alternative when medical therapy for HCM is insufficient.
Abstract:
Hypertrophic cardiomyopathy (HCM) is a clinical entity in which there is unexplained hypertrophy of the left ventricle in the absence of another cardiac or systemic etiology. Variants of HCM may include basal, midventricular, apical or diffuse types. In this review, the authors summarize the current surgical treatment and outcomes of septal myectomy in HCM. HCM is a unique primary myocardial disease characterized by hypertrophy of the myocardium. It is associated with a variety of presentations that range from asymptomatic to sudden cardiac death. Previously known as idiopathic hypertrophic subaortic stenosis, HCM is recognized as a genetic predisposition to myocardial hypertrophy. Medical treatment is the first-line therapy for patients with symptoms due to left ventricular outflow tract obstruction. However, septal myectomy continues to be an excellent treatment option for those intolerant of or unresponsive to medical therapy. In this paper, the authors review the role of surgery in HCM and the different variants of this unique disease.
Related Concept Videos
Cardiomyopathy V: Interprofessional Care
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Cardiomyopathy II: Dilated Cardiomyopathy
Cardiomyopathy VII: Pre and Post Operative Nursing Management
Cardiomyopathy IV: Restrictive Cardiomyopathy
Myocarditis III: Medical Management
