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Updated: May 11, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

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Hematopoietic stem cell transplantation in multiple sclerosis.

Dimitrios Karussis¹, Panayiota Petrou, Urania Vourka-Karussis

¹Department of Neurology, Multiple Sclerosis Center and Laboratory of Neuroimmunology, The Agnes-Ginges Center for Neurogenetics, Hadassah University Hospital, Jerusalem, Ein-Kerem, Israel. karus@cc.huji.ac.il

Expert Review of Neurotherapeutics

|April 30, 2013

Summary

Hematopoietic stem cell transplantation (HSCT) offers a radical approach to multiple sclerosis (MS) by suppressing inflammation. Clinical studies show HSCT can stabilize or improve MS progression, providing a strong proof of concept for its use.

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Area of Science:

Neuroimmunology
Regenerative Medicine
Clinical Trials

Background:

Multiple sclerosis (MS) pathogenesis involves immune-mediated attacks on CNS myelin.
Current MS therapies primarily modulate early disease phases and are less effective in progressive stages.
Localized CNS inflammation drives chronic axonal damage and disability progression in MS.

Purpose of the Study:

To review the rationale for hematopoietic stem cell transplantation (HSCT) in MS.
To summarize the findings of clinical studies evaluating HSCT for MS treatment.
To understand the advantages and disadvantages of different HSCT protocols for MS.

Main Methods:

Review of existing clinical studies on HSCT in MS patients over the last 15 years.
Analysis of outcomes from both autologous and allogeneic HSCT approaches.
Assessment of disease stabilization and improvement post-transplantation.

Main Results:

A high proportion of HSCT-treated MS patients demonstrated disease stabilization or improvement.
HSCT generally showed a beneficial effect on MS disease progression.
Clinical studies provided a strong proof of concept for HSCT in managing MS.

Conclusions:

HSCT represents a potential radical approach for MS by broadly suppressing inflammation.
Despite variations in protocols, HSCT shows promise for stabilizing and improving MS.
Further controlled studies are needed to fully elucidate the benefits and drawbacks of HSCT protocols in MS.