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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Establishment of a Clinic-based Biorepository
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Utilities for advanced basal cell carcinoma.

S L Shingler1, J Garside, K Samanta

  • 1Oxford Outcomes, An ICON plc Company, Oxford, Oxfordshire, UK. sarah.shingler@oxfordoutcomes.com

Journal of Medical Economics
|April 30, 2013
PubMed
Summary

Advanced basal cell carcinoma (aBCC) significantly impacts quality of life, even in stable or post-treatment states. Societal utility values reveal the substantial burden of this rare disease.

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Area of Science:

  • Oncology
  • Health Economics
  • Patient-Reported Outcomes

Background:

  • Advanced basal cell carcinoma (aBCC) presents challenges when standard treatments are not feasible, potentially leading to disfigurement.
  • aBCC can negatively affect patients' psychological well-being, quality of life (QoL), and survival.
  • Quantifying the societal value of health states associated with aBCC is crucial for resource allocation and treatment evaluation.

Purpose of the Study:

  • To determine societal utility values for various health states related to advanced basal cell carcinoma (aBCC).
  • To utilize the time trade-off (TTO) methodology to capture these values from the general public.

Main Methods:

  • Developed nine distinct health states for aBCC, including complete response, partial response, stable disease, and progressive disease, with varying lesion sizes.
  • Employed the time trade-off (TTO) method with 100 UK general public participants.
  • Participants made choices between experiencing a health state for 10 years versus full health for a shorter duration (10-x years) to derive utility scores.

Main Results:

  • The complete response (CR) state had the highest mean utility score (0.94), indicating a minimal impact on QoL.
  • Progressive disease (PD) with a 6 cm lesion yielded the lowest mean utility score (0.67), signifying the greatest negative impact on QoL.
  • Utility scores varied across different states of response and lesion size, reflecting the heterogeneous burden of aBCC.

Conclusions:

  • Societal valuation indicates a significant quality of life burden associated with advanced basal cell carcinoma (aBCC), even in stable or treated conditions.
  • The rarity and variable nature of aBCC pose challenges in characterizing all patient presentations for utility assessment.
  • Findings underscore the importance of considering patient-reported outcomes and societal values in managing advanced basal cell carcinoma.