Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low magnetic fields stimulate cardiac mitochondrial bioenergetics with a bell-shaped response: Possibly via a radical pair mechanism.

Computational and structural biotechnology journal·2025

Same author

Facilitating transformative innovations in sustainability education.

Open research Europe·2023

Same author

Randomized phase 2 trial comparing JNJ-9375, a thrombin-directed antibody, with apixaban for prevention of venous thrombosis.

Journal of thrombosis and haemostasis : JTH·2019

Same author

Heritability in genetic heart disease: the role of genetic background.

Open heart·2019

Same author

Long-term outcomes of cardiac resynchronization therapy by left ventricular ejection fraction.

European journal of heart failure·2018

Same author

Left Ventricular Lead Location and Long-Term Outcomes in Cardiac Resynchronization Therapy Patients.

JACC. Clinical electrophysiology·2018

Search research articles

Related Experiment Videos

Senior academic physicians and retirement considerations.

Arthur J Moss¹, Henry Greenberg, Edward M Dwyer

¹Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642–0653, USA. heartajm@heart.rochester.edu

Progress in Cardiovascular Diseases

|April 30, 2013

Summary

Academic senior physicians nearing retirement offer valuable experience. Planning their career transition and retirement is crucial for both the individual and the institution.

Related Experiment Videos

Area of Science:

Medical Education
Geriatric Medicine
Academic Medicine

Background:

A growing number of senior physicians in academia are healthy and possess extensive clinical and research expertise.
These experienced physicians represent a significant asset to academic medical institutions.
The need to facilitate leadership succession for younger faculty is a key consideration.

Purpose of the Study:

To explore optimal timing and strategies for academic physicians' career transitions into retirement.
To examine the roles for senior faculty as they approach retirement.
To address individual and institutional considerations for retirement planning.

Main Methods:

Exploratory analysis of retirement options for academic medical faculty.
Discussion of individual and institutional factors influencing retirement decisions.
Comparative overview of retirement age norms in the US and Europe.

Main Results:

No fixed retirement age exists in the US, unlike in some European countries.
European physicians are beginning to implement changes in retirement practices.
Retirement involves complex individual and institutional considerations requiring dialogue.

Conclusions:

Careful planning, innovative approaches, and adaptation to new medical practice patterns are essential for senior academic physicians' retirement transition.
Optimizing benefits and minimizing risks for both physicians and institutions requires proactive strategies.
The timing and process of retirement for senior academic physicians necessitate thoughtful consideration.