Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing Body Myopathy in Female Patients With <i>FHL1</i> Variants Showing Rapid and Severe Evolution Mimicking Inflammatory Myopathy: A Case Series.

Neurology. Genetics·2026
Same author

Screening cognitive and academic problems in Duchenne Muscular Dystrophy: Validity and reliability of the Kempenhaeghe Learning Questionnaire.

Journal of neuromuscular diseases·2026
Same author

Understanding the neurobehavioural impact of Duchenne muscular dystrophy: A multicentre European study.

European child & adolescent psychiatry·2026
Same author

High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies.

medRxiv : the preprint server for health sciences·2026
Same author

Acute Neurological Complications After Transplantation in Methylmalonic Acidemia: A 35-Patient French Cohort.

Journal of inherited metabolic disease·2026
Same author

Laminopathies: natural history and risk prediction of heart failure.

European heart journal·2026

Related Experiment Video

Updated: May 11, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

Clinical and imaging diagnosis for heredodegenerative diseases.

Nathalie Boddaert1, Francis Brunelle, Isabelle Desguerre

  • 1Department of Pediatric Radiology, Hôpital Necker - Enfants Malades and Medical Faculty, Université Paris Descartes, Paris, France.

Handbook of Clinical Neurology
|April 30, 2013
PubMed
Summary

Brain imaging, including CT and MRI, is crucial for diagnosing neurological disorders characterized by psychomotor retardation and seizures. Advanced MRI techniques like spectroscopy can detect metabolic changes and aid in early diagnosis, even preclinically.

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Related Experiment Videos

Last Updated: May 11, 2026

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

Area of Science:

  • Neurology
  • Radiology
  • Neuroimaging

Background:

  • Diagnosis of neurological disorders relies on clinical features like psychomotor retardation, seizures, and movement disorders.
  • Brain imaging plays a pivotal role in identifying structural and metabolic abnormalities.

Purpose of the Study:

  • To outline the diagnostic utility of various neuroimaging techniques in identifying key clinical features of neurological disorders.
  • To detail the specific sequences and applications of CT, MRI, and MR spectroscopy in diagnosing these conditions.

Main Methods:

  • Computed Tomography (CT) for calcifications, blood detection, and angiography.
  • Magnetic Resonance Imaging (MRI) with T1, T2, FLAIR, T2*, contrast, and diffusion sequences.
  • Magnetic Resonance Spectroscopy (MRS) to detect metabolic markers like lactate, creatine, choline, and N-acetylaspartate (NAA).

Main Results:

  • CT detects calcifications and blood; MRI visualizes structural anomalies across different planes.
  • MRS identifies metabolic alterations indicative of neuronal death or high membrane turnover.
  • Imaging can reveal anomalies from neonatal period through infancy, including basal ganglia, white matter, and cerebellar abnormalities.
  • MRI can detect preclinical brain alterations in siblings of affected children.

Conclusions:

  • A combination of clinical evaluation and advanced neuroimaging is essential for accurate diagnosis.
  • MRI and MRS provide critical insights into structural and metabolic changes, aiding early and preclinical diagnosis.
  • Understanding normal myelination sequences is vital for interpreting imaging findings.