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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT
10:53

Functional Imaging of Brown Fat in Mice with 18F-FDG micro-PET/CT

Published on: November 23, 2012

Functional imaging: PET.

Ajay Kumar1, Harry T Chugani

  • 1Departments of Pediatrics and Neurology, School of Medicine, Wayne State University, and PET Center, Children's Hospital of Michigan, Detroit, MI, USA.

Handbook of Clinical Neurology
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

Positron emission tomography (PET) is crucial for evaluating children with intractable epilepsy, especially for identifying focal cortical dysplasia. PET imaging offers unique insights in infants and specific conditions like tuberous sclerosis, aiding in epilepsy network and cognitive function assessment.

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Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Epileptology

Background:

  • Intractable epilepsy in children presents diagnostic challenges.
  • Magnetic Resonance Imaging (MRI) may be limited by incomplete myelination in infants.
  • Positron Emission Tomography (PET) offers advanced neuroimaging capabilities.

Purpose of the Study:

  • To highlight the role of PET in evaluating pediatric intractable epilepsy.
  • To demonstrate PET's utility in localizing epileptogenic zones.
  • To explore PET's application in various epilepsy syndromes and related neurological processes.

Main Methods:

  • Utilizing various PET tracers for neuroimaging.
  • Comparing PET findings with MRI in pediatric epilepsy cases.
  • Applying PET to investigate specific epilepsy syndromes and cognitive functions.

Main Results:

  • PET effectively localizes focal cortical dysplasia, crucial in infants.
  • PET differentiates epileptogenic from non-epileptogenic tubers in tuberous sclerosis.
  • PET reveals abnormalities in infantile spasms and Landau-Kleffner syndrome.
  • PET aids in understanding epileptic networks, dual pathology, and neuroinflammation.

Conclusions:

  • PET is a vital tool for diagnosing and understanding intractable epilepsy in children.
  • PET provides unique diagnostic information where MRI is limited.
  • PET contributes to assessing cognitive function and brain plasticity in pediatric epilepsy.