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Proofreading and DNA Repair Assay Using Single Nucleotide Extension and MALDI-TOF Mass Spectrometry Analysis
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On your mark, get SET(D2), go! H3K36me3 primes DNA mismatch repair
Christine K Schmidt1, Stephen P Jackson
1The Gurdon Institute and the Department of Biochemistry, University of Cambridge, Cambridge, UK.
Cell
|April 30, 2013
Abstract
None:
Trimethylation of histone H3 on Lys36 (H3K36me3) by SETD2 is linked to actively transcribed regions. Li et al. identify a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR machinery to chromatin during the cell cycle, thereby explaining certain cases of MMR-defective cancers.
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