Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The History of Intramedullary Spinal Cord Tumor Surgery.

Neurosurgery clinics of North America·2026
Same author

Intramedullary Spinal Cord Tumors.

Neurosurgery clinics of North America·2026
Same author

Decompression with or without Duraplasty for Chiari I and Syringomyelia.

The New England journal of medicine·2026
Same author

Understanding barriers to pediatric hydrocephalus management: an international survey.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same author

Radiologic characterization and clinical management of multinodular and vacuolating neuronal tumor (MVNT): a retrospective institutional cohort study.

Journal of neuro-oncology·2025
Same author

Leukocyte-intrinsic ER stress responses contribute to chemotherapy-induced peripheral neuropathy.

Science translational medicine·2025
Same journal

Preface.

Handbook of clinical neurology·2026
Same journal

Foreword.

Handbook of clinical neurology·2026
Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026
Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026
Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026
Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Pediatric spinal tumors.

Wesley Hsu1, George I Jallo

  • 1Wake Forest Baptist Hospital, Department of Neurosurgery, Winston-Salem, North Carolina, USA.

Handbook of Clinical Neurology
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

Pediatric spinal cord tumors, though rare, require multidisciplinary care. Surgical resection is key for treating these tumors, with outcomes depending on histology, resection extent, and neurological status.

More Related Videos

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Related Experiment Videos

Last Updated: May 11, 2026

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point
03:13

Endoscopic Third Ventriculostomy and Pineal Biopsy from a Single Entry Point

Published on: June 28, 2024

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

Area of Science:

  • Pediatric Oncology
  • Neurology
  • Neurosurgery

Background:

  • Spinal cord tumors are less than 10% of pediatric central nervous system tumors.
  • Tumors can be intramedullary, intradural extramedullary, or extradural.
  • Common types include astrocytomas and ependymomas in the intramedullary space.

Purpose of the Study:

  • To review the characteristics, presentation, and management of pediatric spinal cord tumors.
  • To highlight the importance of a multidisciplinary approach.
  • To identify predictors of patient outcomes.

Main Methods:

  • Review of existing literature on pediatric spinal cord tumors.
  • Analysis of tumor types, locations, and presenting symptoms.
  • Discussion of treatment modalities and prognostic factors.

Main Results:

  • Intramedullary tumors (astrocytomas, ependymomas) are most common.
  • Presenting symptoms include pain, motor regression, and gait disturbances.
  • Surgical resection is the primary treatment modality.

Conclusions:

  • Pediatric spinal cord tumors necessitate a comprehensive, multidisciplinary approach.
  • Histological grade, extent of resection, and preoperative neurological status are crucial for outcomes.
  • Timely diagnosis and appropriate treatment are vital for improving patient prognosis.