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Comparative Analysis of Automatic Fecal Analyzer versus Direct Wet Smear Microscopy for Detecting Parasitic Infections in Stool Samples
Published on: April 25, 2025
Parasitic disorders
Charles R Newton1, Pierre-Marie Preux, Prathiba Singhi
1KEMRI-Wellcome Collaborative Programme, Kilifi, Kenya.
Insights
Parasitic central nervous system infections in children are rising globally, impacting neurological health. Early diagnosis and treatment are crucial for managing these serious pediatric conditions.
Area of Science:
- Pediatric Neurology
- Infectious Diseases
- Tropical Medicine
Background:
- Parasitic central nervous system (CNS) infections in children are prevalent in resource-poor and tropical regions.
- Increasing global travel and migration are leading to a rise in these infections in Western countries.
- These parasitic conditions are critical considerations in the differential diagnosis of pediatric neurological syndromes.
Purpose of the Study:
- To highlight the significance of parasitic CNS infections in pediatric neurology.
- To discuss common parasitic causes of neurological dysfunction in children.
- To emphasize the importance of considering these infections in the differential diagnosis.
Main Methods:
- Review of literature on parasitic CNS infections in children.
- Discussion of specific parasitic etiologies and their neurological manifestations.
- Emphasis on diagnostic considerations and potential treatments.
Main Results:
- Falciparum malaria, neurocysticercosis, schistosomiasis, and toxocariasis are key parasitic causes of neurological disease in children.
- These infections can manifest as seizures, coma, epilepsy, spinal cord disease, encephalitis, and retinal changes.
- Eosinophilia is a common associated finding, though not exclusive to parasitic causes of meningoencephalitis.
Conclusions:
- Parasitic CNS infections represent a growing global health concern for children, requiring increased awareness.
- Prompt recognition and diagnosis are essential for effective management and improved outcomes.
- While many parasitic infections are treatable, the impact of treatment on long-term outcomes requires further investigation.
Abstract:
Parasites infect the central nervous system of children, particularly in resource-poor areas and tropical countries. However, these infections are increasingly seen in the West with the increase in children travelling to these areas and immigrant populations. These conditions are important in the differential diagnosis of common neurological syndromes. Falciparum malaria is a common cause of seizures and coma in endemic areas. Neurocysticercosis is a common cause of acquired epilepsy in some areas. Schistosomiasis is an important cause of spinal cord disease. Toxocara is ubiquitous and may cause encephalitis and retinal changes, and may be associated with epilepsy. Other parasitic conditions tend to be localized to specific regions of the world. Parasitic diseases are often associated with eosinophilia, and some cause an eosinophilic meningoencephalitis, although there are many nonparasitic causes of this syndrome. Most parasitic conditions can be treated, but in some diseases it is unclear whether the treatment influences outcome.
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