Parasitic disorders

Charles R Newton1, Pierre-Marie Preux, Prathiba Singhi

  • 1KEMRI-Wellcome Collaborative Programme, Kilifi, Kenya.

Insights

Parasitic central nervous system infections in children are rising globally, impacting neurological health. Early diagnosis and treatment are crucial for managing these serious pediatric conditions.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Tropical Medicine

Background:

  • Parasitic central nervous system (CNS) infections in children are prevalent in resource-poor and tropical regions.
  • Increasing global travel and migration are leading to a rise in these infections in Western countries.
  • These parasitic conditions are critical considerations in the differential diagnosis of pediatric neurological syndromes.

Purpose of the Study:

  • To highlight the significance of parasitic CNS infections in pediatric neurology.
  • To discuss common parasitic causes of neurological dysfunction in children.
  • To emphasize the importance of considering these infections in the differential diagnosis.

Main Methods:

  • Review of literature on parasitic CNS infections in children.
  • Discussion of specific parasitic etiologies and their neurological manifestations.
  • Emphasis on diagnostic considerations and potential treatments.

Main Results:

  • Falciparum malaria, neurocysticercosis, schistosomiasis, and toxocariasis are key parasitic causes of neurological disease in children.
  • These infections can manifest as seizures, coma, epilepsy, spinal cord disease, encephalitis, and retinal changes.
  • Eosinophilia is a common associated finding, though not exclusive to parasitic causes of meningoencephalitis.

Conclusions:

  • Parasitic CNS infections represent a growing global health concern for children, requiring increased awareness.
  • Prompt recognition and diagnosis are essential for effective management and improved outcomes.
  • While many parasitic infections are treatable, the impact of treatment on long-term outcomes requires further investigation.

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