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Updated: May 11, 2026
08:58
Murine Kidney Transplant Technique
Published on: October 20, 2015
Pediatric renal transplantation: a single center experience
A Kavaz1, Z B Özçakar, B Bulum
1Department of Pediatric Nephrology, Ankara University School of Medicine, Ankara, Turkey.
Transplantation Proceedings
|April 30, 2013
Summary
Pediatric kidney transplantation is effective for end-stage renal disease. Post-transplant infection, particularly viral infections, remains a significant concern for young allograft recipients.
Area of Science:
- Pediatric Nephrology
- Transplantation Immunology
- Infectious Diseases in Immunocompromised Patients
Background:
- End-stage renal disease (ESRD) in children necessitates renal replacement therapy.
- Renal transplantation is the preferred treatment modality for pediatric ESRD.
- Understanding outcomes and complications in pediatric renal allograft recipients is crucial.
Purpose of the Study:
- To retrospectively evaluate the outcomes of pediatric renal allograft recipients.
- To identify the incidence of acute rejection and serious infections post-transplantation.
- To assess patient survival and causes of mortality in this cohort.
Main Methods:
- Retrospective analysis of 37 pediatric renal allograft recipients (July 2007 - August 2012).
- Data collected included patient demographics, transplantation details, follow-up duration, rejection episodes, infections, and mortality.
- Analysis of specific viral infections (cytomegalovirus, parvovirus, BK virus, Ebstein-Barr virus) and their impact.
Main Results:
- A total of 37 children underwent renal transplantation, with a mean age of 12.16 years.
- 8.1% received preemptive transplants; 81% received living donor grafts.
- Acute rejection occurred in 16.2% of patients. Serious viral infections were common (29.7%), with cytomegalovirus being most frequent (n=8). Three deaths were reported, primarily due to infection-related complications.
Conclusions:
- Kidney transplantation is a viable and effective treatment for pediatric end-stage renal disease.
- Infection, particularly viral infections, represents the most significant post-transplant complication in pediatric renal allograft recipients.
- Close monitoring and management of infections are essential for improving outcomes in this population.
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