Pediatric kidney transplantation: a single center experience with 134 procedures

Area of Science:

• Pediatric Nephrology
• Transplantation Surgery
• Immunology

Background:

• End-stage renal disease (ESRD) significantly impacts children's growth and quality of life.
• Renal transplantation offers substantial benefits for pediatric ESRD patients.
• Long-term outcomes of pediatric renal transplantation require continuous evaluation.

Purpose of the Study:

• To report the experience and outcomes of 134 pediatric renal transplantations.
• To analyze epidemiological and clinical data of young renal transplant recipients.
• To assess graft survival and patient outcomes in a pediatric cohort.

Main Methods:

• Prospective database collection of patients under 18 years old undergoing renal transplantation.
• Analysis of data from January 1984 to May 2012.
• Evaluation of graft survival, patient survival, and renal function.

Main Results:

• 124 patients underwent 134 renal transplantations, with obstructive uropathy and nephropathy as primary causes of ESRD.
• 5- and 10-year graft survival rates were 84.1% and 71.9%, respectively.
• 96% of recipients were alive, with 71% having functioning allografts and a mean GFR of 55 mL/min.

Conclusions:

• Renal transplantation is a beneficial treatment option for pediatric patients with ESRD.
• The study demonstrates favorable long-term graft and patient survival rates.
• Pediatric renal transplantation leads to improved quality of life and renal function.